4Plex®

4Plex® is a balanced combination of:
ZINPRO® zinc methionine
MANPRO® manganese methionine
CuPLEX®copper lysine
COPRO® cobalt glucoheptonate

Trace minerals are required for numerous metabolic functions: growth and development, immunity, reproduction and lactation. Supplying zinc (Zn), manganese (Mn), copper (Cu) and cobalt (Co) in a highly bioavailable form has shown benefits for these functions. Response to stress is also affected by an animal’s trace mineral status. Negative effects from stress are reduced when animals have adequate trace mineral status and are consuming a balanced diet with readily bioavailable minerals.

BovineBenefits
Hoof Condition
Zn
 Cell division to support hoof wall growth and repair
 Hoof wall protein synthesis: collagen, keratins, cell envelope proteins and intercellular cementing substance

Cu 
 Synthesis and maintenance of elastic connective tissue 
 Cross-linkage formation in collagen and elastin
 Bond formation in hoof wall proteins for rigidity

Mn 
 Antioxidant activity to protect cell membranes

Joints and Skeleton
Zn
 Cell division and protein synthesis for skeletal growth and repair

Cu
 Formation of connective tissue (tendons and ligaments) bones and cartilage lining joints

Mn
 Chondroitin sulfate synthesis which is important for formation, maintenance and repair of joint cartilage
 Bone matrix development and maintenance

Immune Response
Zn, Mn and Cu
 Humoral immunity: antibody titers in response to vaccination
 Cell-mediated immunity
 Non-specific immunity
 Antioxidant activity to remove free radicals and protect cell membranes

Skin and Coat
Zn and Mn
 Epidermal (skin) cell maintenance through cell division, protein synthesis and antioxidant activity to remove superoxide radicals
 Facilitates wound healing

Cu
 Normal production and maintenance of skin and hair pigmentation

Feed Digestibility
Co
 Cecal fiber digestion by bacteria resulting in increase energy availability from forage
 Vitamin B12 synthesis

Reproduction
Zn 
 Reproductive tract tissue integrity 
 Conception rates
 Sperm maturation and quality

Cu
 Early embryonic survival
 Estrus and conception rates 
 Central nervous system development in offspring

Mn
Reproductive hormone synthesis
 Male libido
 Fetal skeletal development